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KMID : 1094719980030020091
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Biotechnology and Bioprocess Engineering
1998 Volume.3 No. 2 p.91 ~ p.91
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Elicitation of camptothecin production in cell cultures ofCamptotheca acuminata
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Song Seung-Hoon
Byun Sang-Yo
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Abstract
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Campothecin production was increased with elicitors, methyl jasmonate, jasmonic acid, yeast extract elicitor, and ferulic acid in suspension cultures ofCamptotheca acuminata. jasmonic acid was found to be the most efficient elicitor. Camptothecin production increased 11 times by using the optimum dosing concentration of jasmonic acid which was 50 μM. The kinetics of camptothecin accumulation in response to the treatment with jasmonic acid showed that the camptothecin accumulation reached the maximum value at 4 days after jasmonic acid dosing and then a rapid decrease in camptothecin accumulation was observed.
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KEYWORD
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camptothecin, Camptotheca acuminata, elicitor, jasmonic acid
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